Hari pertama Latihan Industri banyak perkara baharu yang ana peroleh. Antaranya tentang terma-terma saintifik dan alatan canggih untuk mempercepat ujikaji.
Exome sequencing: a.k.a targeted exome capture is an efficient strategy to selectively sequence the coding regions of the human genome to identify novel genes associated with rare and common disorders. The “exome” represents all the exons in the human genome (i.e., the protein-coding region of the genome). Exons are short, functionally important sequences of DNA which represent the regions in genes that are translated into protein. In total there are about 180,000 exons found in the human genome. These protein coding regions constitute about 1% of the human genome which translates to about 30 megabases (Mb) in length. It is estimated that the protein coding regions of the human genome constitute about 85% of the disease-causing mutations.
Kinome: set of protein kinases in its genome. Kinases are enzymes that catalyze phosphorylation reactions (of amino acids) and fall into several groups and families, e.g., those that phosphorylate the amino acids, serine and threonine, those that phosphorylate tyrosine and some that can phosphorylate both, such as the MAP2K and GSK families. The term was first used in 2002 by Gerard Manning and colleagues in twin papers analyzing the 518 human protein kinases and the evolution of protein kinases throughout eukaryotes. Other kinomes have been determined for rice, several fungi, nematodes, and insects, sea urchins.
As kinases are a major drug target and a major control point in cell behavior, the kinome has also been the target of large scale functional genomics with RNAi screens and of drug discovery efforts, especially in cancer therapeutics.